IGF-I R/IGF1R Antibody MAB391-100 from R&D Systems, a Bio-Techne Brand

Product Specs
ItemIGF-I R/IGF1R Antibody
CompanyR&D Systems, a Bio-Techne Brand
Price Pricing Info Supplier Page View Company Product Page
Catalog NumberMAB391-100
Quantity100 ug (also 500 ug, 25 ug)
ApplicationsWestern Blot, Flow Cytometry, Immunohistochemistry, Neutralization, Immunocytochemistry, ELISA Capture (Matched Antibody Pair)
Conjugate/TagUnconjugated
FormatLyophilized from a 0.2 µm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS
ReactivityHuman, Mouse
TargetIGF-I R/IGF1R
IsotypeIgG1
Clone33255
HostMouse
ImmunogenS. frugiperda insect ovarian cell line Sf 21-derived recombinant human IGF-I R/IGF1R, Glu31-Asn932, Accession # P08069
NCBI Full Gene Nameinsulin like growth factor 1 receptor
NCBI Gene AliasesIGFR, IGFIR, CD221, JTK13
ClonalityMonoclonal
Brand/TrademarkR&D Systems, a Bio-Techne Brand
PurityProtein A or G purified from hybridoma culture supernatant
Antibody TypePrimary Antibodies
StorageUse a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 6 months, -20 to -70 °C under sterile conditions after reconstitution

Specifications/Features

Available conjugates: Unconjugated

Specificity: Detects human IGF-I R/IGF1R in sandwich ELISAs and Western blots. Detects mouse IGF-I R/IGF1R in Immunohistochemistry. In sandwich immunoassays, less than 0.15% cross-reactivity or interference was observed with recombinant human (rh) IGF-I, rhIGF-II, rhIL-3 R alpha, rhIL-9 R, and rhTGF-beta RII

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R&D Systems, a Bio-Techne Brand

614 McKinley Place N.E.

Minneapolis, Minnesota 55413

United States

Phone: 1 (800) 343-7475
1 (612) 379-2956

Fax: 1 (612) 656-4400

Company Profile

Website: http://www.rndsystems.com

(1) Blocking insulin-like growth factor 1 receptor signaling pathway inhibits neuromuscular junction regeneration after botulinum toxin-A treatmentCell death & diseaseSeptember 16, 2023Ishihara H, Otani Y, Tanaka K, Miyajima H, Ngo HX, Fujitani M.

(2) Osteoclast-derived IGF1 induces RANKL production in osteocytes and contributes to pagetic lesion formationJCI insightJuly 24, 2023Miyagawa K, Tenshin H, Mulcrone PL, Delgado-Calle J, Subler MA, Windle JJ, Chirgwin JM, Roodman GD, Kurihara N.

(3) Synergistic activity of agents targeting growth factor receptors, CDKs and downstream signaling molecules in a panel of pancreatic cancer cell lines and the identification of antagonistic combinations: Implications for future clinical trials in pancreatic cancerOncology reportsDecember 1, 2020Khan T, Seddon AM, Dalgleish AG, Khelwatty S, Ioannou N, Mudan S, Modjtahedi H.

(4) Tough Composite Hydrogels with High Loading and Local Release of Biological DrugsAdvanced healthcare materialsMay 1, 2018Li J, Weber E, Guth-Gundel S, Schuleit M, Kuttler A, Halleux C, Accart N, Doelemeyer A, Basler A, Tigani B, et al.

(5) IGF1R activation and the in vitro antiproliferative efficacy of IGF1R inhibitor are inversely correlated with IGFBP5 expression in bladder cancerBMC cancerSeptember 7, 2017Neuzillet Y, Chapeaublanc E, Krucker C, De Koning L, Lebret T, Radvanyi F, Bernard-Pierrot I.

(6) Impact of the putative cancer stem cell markers and growth factor receptor expression on the sensitivity of ovarian cancer cells to treatment with various forms of small molecule tyrosine kinase inhibitors and cytotoxic drugsInternational journal of oncologyNovember 1, 2016Puvanenthiran S, Essapen S, Seddon AM, Modjtahedi H.

(7) A SPOPL/Cullin-3 ubiquitin ligase complex regulates endocytic trafficking by targeting EPS15 at endosomeseLifeMarch 23, 2016Gschweitl M, Ulbricht A, Barnes CA, Enchev RI, Stoffel-Studer I, Meyer-Schaller N, Huotari J, Yamauchi Y, Greber UF, Helenius A, et al.

(8) Insulin and IGF1 signalling pathways in human astrocytes in vitro and in vivo; characterisation, subcellular localisation and modulation of the receptorsMolecular brainAugust 22, 2015Garwood CJ, Ratcliffe LE, Morgan SV, Simpson JE, Owens H, Vazquez-Villaseñor I, Heath PR, Romero IA, Ince PG, Wharton SB.

(9) Targeting both IGF-1R and mTOR synergistically inhibits growth of renal cell carcinoma in vitroBMC cancerApril 1, 2013Cardillo TM, Trisal P, Arrojo R, Goldenberg DM, Chang CH.

(10) Insulin-like growth factor 1 and 2 (IGF1, IGF2) expression in human microglia: differential regulation by inflammatory mediatorsJournal of neuroinflammationMarch 12, 2013Suh HS, Zhao ML, Derico L, Choi N, Lee SC.

(11) Proinflammatory actions of visfatin/nicotinamide phosphoribosyltransferase (Nampt) involve regulation of insulin signaling pathway and Nampt enzymatic activityThe Journal of biological chemistryApril 27, 2012Jacques C, Holzenberger M, Mladenovic Z, Salvat C, Pecchi E, Berenbaum F, Gosset M.

(12) Expression of the IGF axis is decreased in local prostate cancer but enhanced after benign prostate epithelial differentiation and TGF-β treatmentThe American journal of pathologyDecember 1, 2011Massoner P, Ladurner Rennau M, Heidegger I, Kloss-Brandstätter A, Summerer M, Reichhart E, Schäfer G, Klocker H.

(13) Autologous bone marrow stromal cells genetically engineered to secrete an igf-I receptor decoy prevent the growth of liver metastasesMolecular therapy : the journal of the American Society of Gene TherapyJuly 1, 2009Wang N, Fallavollita L, Nguyen L, Burnier J, Rafei M, Galipeau J, Yakar S, Brodt P.

(14) Changes in insulin and IGF-I receptor expression during differentiation of human preadipocytesGrowth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research SocietyApril 1, 2009Bäck K, Arnqvist HJ.

(15) Resistance of acute myeloid leukemic cells to the triterpenoid CDDO-Imidazolide is associated with low caspase-8 and FADD levelsLeukemia researchAugust 1, 2008Riccioni R, Senese M, Diverio D, Riti V, Mariani G, Boe A, LoCoco F, Foà R, Peschle C, Sporn M, et al.

(16) Mesenchymal stem cell abnormalities in patients with multiple myelomaLeukemia & lymphomaOctober 1, 2007Garderet L, Mazurier C, Chapel A, Ernou I, Boutin L, Holy X, Gorin NC, Lopez M, Doucet C, Lataillade JJ.

(17) Expression of Tie-2 and other receptors for endothelial growth factors in acute myeloid leukemias is associated with monocytic features of leukemic blastsStem CellsAugust 1, 2007Riccioni R, Diverio D, Mariani G, Buffolino S, Riti V, Saulle E, Petrucci E, Cedrone M, Lo-Coco F, Foà R, et al.

(18) Insulin-like growth factor (IGF) 2 stimulates steroidogenesis and mitosis of bovine granulosa cells through the IGF1 receptor: role of follicle-stimulating hormone and IGF2 receptorBiology of reproductionJuly 1, 2007Spicer LJ, Aad PY.

(19) The susceptibility of granulosa cells to apoptosis is influenced by oestradiol and the cell cycleThe Journal of endocrinologyJune 1, 2006Quirk SM, Cowan RG, Harman RM.